Cancer-associated fibroblasts (CAFs) are increasingly recognized as playing a crucial role in regulating cancer progression and metastasis. These cells can be activated by long non-coding RNAs (lncRNAs), promoting the malignant biological processes of tumor cells. Therefore, it is essential to understand the regulatory relationship between CAFs and lncRNAs in cancers. Here, we identified CAF-related lncRNAs at the pan-cancer level to systematically predict their potential regulatory functions. The identified lncRNAs were also validated using various external data at both tissue and cellular levels. This study has revealed that these CAF-related lncRNAs exhibit expression perturbations in cancers and are highly correlated with the infiltration of stromal cells, particularly fibroblasts and endothelial cells. By prioritizing a list of CAF-related lncRNAs, we can further distinguish patient subtypes that show survival and molecular differences. In addition, we have developed a web server, CAFLnc (https://46906u5t63.zicp.fun/CAFLnc/), to visualize our results. In conclusion, CAF-related lncRNAs hold great potential as a valuable resource for comprehending lncRNA functions and advancing the identification of biomarkers for cancer progression and therapeutic targets in cancer treatment.

中文翻译：

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在泛癌水平上鉴定 CAF 相关 lncRNA 具有潜在的致癌风险

人们越来越认识到癌症相关成纤维细胞（CAF）在调节癌症进展和转移中发挥着至关重要的作用。这些细胞可以被长链非编码RNA（lncRNA）激活，促进肿瘤细胞的恶性生物学过程。因此，了解癌症中 CAF 和 lncRNA 之间的调控关系至关重要。在这里，我们在泛癌水平上鉴定了与 CAF 相关的 lncRNA，以系统地预测其潜在的调节功能。还使用组织和细胞水平上的各种外部数据对识别出的 lncRNA 进行了验证。这项研究表明，这些与 CAF 相关的 lncRNA 在癌症中表现出表达扰动，并且与基质细胞（特别是成纤维细胞和内皮细胞）的浸润高度相关。通过优先考虑 CAF 相关 lncRNA 列表，我们可以进一步区分表现出生存和分子差异的患者亚型。此外，我们还开发了一个网络服务器 CAFLnc (https://46906u5t63.zicp.fun/CAFLnc/)，以可视化我们的结果。总之，CAF 相关的 lncRNA 作为理解 lncRNA 功能和推进癌症进展生物标志物的识别和癌症治疗中的治疗靶点的宝贵资源具有巨大的潜力。