Focal seizures are a type of epileptic event that has plagued the medical community for a long time, and the existing drug treatment is mainly based on the modulation of ${GABA}_a$-receptors to affect GABAergic signaling to achieve the therapeutic purpose. The majority of research currently focuses on the impact of ${GABA}_a$-receptors on neuronal firing, failing to analyze the molecular and ionic mechanisms involved. Specifically, the research on deeper-level mechanisms on how ${GABA}_a$-receptors affect neuronal firing by altering ion activity has not been addressed. This research aimed to study the effects of different ${GABA}_a$-receptor structures on ion activity in focal seizures model by adjusting parameters of the ${GABA}_a$-receptors: the rise time constant (${tau}_1$) and decay time constant (${tau}_2$). The research indicates that as the values of ${tau}_1$ and ${tau}_2$ of the ${GABA}_a$-receptor change, the ion concentration will vary based on the change of the ${GABA}_a$-receptor potential. To a certain extent, the duration of epileptic activity will also be affected to a certain extent. In conclusion, the alteration of ${GABA}_a$-receptor structure will affect the inhibitory effect of interneurons on pyramidal neurons, and different parameters of the ${GABA}_a$-receptor will directly impact the therapeutic effect.

中文翻译：

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GABAa 受体对局灶性癫痫发作中神经元放电和离子活性的影响

局灶性癫痫发作是长期困扰医学界的一类癫痫事件，现有的药物治疗主要是通过调节${GABA}_a$-受体来影响GABAergic信号传导来达到治疗目的。目前大多数研究都集中在${GABA}_a$-受体对神经元放电的影响上，未能分析所涉及的分子和离子机制。具体来说，关于${GABA}_a$-受体如何通过改变离子活性影响神经元放电的更深层次机制的研究尚未得到解决。本研究旨在通过调整${GABA}_a$-受体的参数：上升时间常数(${tau}_1$ ）和衰减时间常数（${tau}_2$）。研究表明，随着${GABA}_a$受体的${tau}_1$和${tau}_2$值的变化，离子浓度也会随着${GABA}_a$的变化而变化。 -受体电位。在一定程度上，癫痫活动的持续时间也会受到一定的影响。总之，${GABA}_a$-受体结构的改变会影响中间神经元对锥体神经元的抑制作用，而${GABA}_a$-受体的不同参数将直接影响治疗效果。