Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation remains cryptic. Four decades ago, the nature of the N terminus was linked to protein stability. In this Comment, we discuss an emerging major role of N-terminal acetylation in shielding the proteome from degradation. Thomas Arnesen and colleagues discuss an emerging major role of one of the most common protein modifications, N-terminal acetylation, in shielding the proteome from degradation.

中文翻译：

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蛋白质N端乙酰化正在进入降解终局

尽管 N 末端乙酰化是真核生物中最常见的蛋白质修饰之一，但它对细胞的影响仍然很神秘。四十年前，N 末端的性质与蛋白质稳定性有关。在这篇评论中，我们讨论了 N 末端乙酰化在保护蛋白质组免遭降解方面的新兴重要作用。 Thomas Arnesen 及其同事讨论了最常见的蛋白质修饰之一（N 端乙酰化）在保护蛋白质组免遭降解方面的新兴主要作用。