当前位置：
X-MOL 学术
›
J. Cell. Mol. Med.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease
Journal of Cellular and Molecular Medicine ( IF 5.3 ) Pub Date : 2024-03-23 , DOI: 10.1111/jcmm.18229 Hsiang‐Ching Huang, Yi‐Hsien Hsieh, Chi‐Hao Hsiao, Chia‐Yen Lin, Shian‐Shiang Wang, Kuo‐Hao Ho, Lun‐Ching Chang, Huei‐Mei Huang, Shun‐Fa Yang, Ming‐Hsien Chien
Journal of Cellular and Molecular Medicine ( IF 5.3 ) Pub Date : 2024-03-23 , DOI: 10.1111/jcmm.18229 Hsiang‐Ching Huang, Yi‐Hsien Hsieh, Chi‐Hao Hsiao, Chia‐Yen Lin, Shian‐Shiang Wang, Kuo‐Hao Ho, Lun‐Ching Chang, Huei‐Mei Huang, Shun‐Fa Yang, Ming‐Hsien Chien
Monoamine oxidase B (MAOB), a neurotransmitter‐degrading enzyme, was reported to reveal conflicting roles in various cancers. However, the functional role of MAOB and impacts of its genetic variants on prostate cancer (PCa) is unknown. Herein, we genotyped four loci of MAOB single‐nucleotide polymorphisms (SNPs), including rs1799836 (A/G), rs3027452 (G/A), rs6651806 (A/C) and rs6324 (G/A) in 702 PCa Taiwanese patients. We discovered that PCa patients carrying the MAOB rs6324 A‐allele exhibited an increased risk of having a high initial prostate‐specific antigen (iPSA) level (>10 ng/mL). Additionally, patients with the rs3027452 A‐allele had a higher risk of developing distal metastasis, particularly in the subpopulation with high iPSA levels. In a subpopulation without postoperative biochemical recurrence, patients carrying the rs1799836 G‐allele had a higher risk of developing lymph node metastasis and recurrence compared to those carrying the A‐allele. Furthermore, genotype screening in PCa cell lines revealed that cells carrying the rs1799836 G‐allele expressed lower MAOB levels than those carrying the A‐allele. Functionally, overexpression and knockdown of MAOB in PCa cells respectively suppressed and enhanced cell motility and proliferation. In clinical observations, correlations of lower MAOB expression levels with higher Gleason scores, advanced clinical T stages, tumour metastasis, and poorer prognosis in PCa patients were noted. Our findings suggest that MAOB may act as a suppressor of PCa progression, and the rs3027452 and rs1799836 genetic variants of MAOB are linked to PCa metastasis within the Taiwanese population.
更新日期：2024-03-23
京公网安备 11010802027423号