Penile squamous cell carcinoma (PSCC) is a rare tumor with an aggressive behavior. The Meet-URO 23/I-RARE registry includes rare genitourinary malignancies. We extracted patients with PSCC to conduct a retrospective study aimed at assessing clinical outcomes and prognostic factors. Primary endpoints were overall survival and progression-free survival. Prognostic factors for OS and PFS were analyzed using univariate and multivariate analysis. In the overall population, median OS from diagnosis was 34.6 months. Significant differences in median OS were observed according to ECOG PS at diagnosis (57.3 months 8.3 months; < .001), and median age (≤77y 88.8 months >77y 26 months; = .013). At multivariate analysis, ECOG PS 2-4 at diagnosis (HR 3.04) and lymph node metastases (HR 2.49) were independently associated with a higher risk of death. In our registry study, PSCC is confirmed to be an aggressive disease. Poor ECOG PS, presence of lymph node metastases, and higher age at diagnosis appear to be associated with worse survival outcomes.

中文翻译：

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阴茎癌患者的临床结果和预后因素：Meet-URO 23 (I-RARE) 注册研究的子分析

阴茎鳞状细胞癌（PSCC）是一种具有侵袭性的罕见肿瘤。 Meet-URO 23/I-RARE 注册表包括罕见的泌尿生殖系统恶性肿瘤。我们抽取 PSCC 患者进行回顾性研究，旨在评估临床结果和预后因素。主要终点是总生存期和无进展生存期。使用单变量和多变量分析来分析 OS 和 PFS 的预后因素。在总体人群中，诊断后的中位 OS 为 34.6 个月。根据诊断时的 ECOG PS，观察到中位 OS 存在显着差异（57.3 个月 8.3 个月；< .001），中位年龄（≤77 岁 88.8 个月 >77 岁 26 个月；= .013）。在多变量分析中，诊断时的 ECOG PS 2-4 (HR 3.04) 和淋巴结转移 (HR 2.49) 与较高的死亡风险独立相关。在我们的登记研究中，PSCC 被证实是一种侵袭性疾病。 ECOG PS 较差、存在淋巴结转移以及诊断时年龄较高似乎与较差的生存结果相关。