As a new marker of inflammation and lipid metabolism, the ratio of myeloperoxidase to high density lipoprotein (MPO/HDL) has been reported in the field of cardiovascular disease. However, the effect of MPO/HDL on acute ischemic stroke (AIS) is not clear. The purpose of this study was to explore the prognostic value of MPO/HDL level in patients with AIS. This study conducted a retrospective analysis of 363 patients diagnosed with AIS. Stroke severity was assessed by National Institutes of Health Stroke Scale (NIHSS). The short-term functional outcome was evaluated with modified Rankin Scale (mRS) 90 days after admission. Spearman correlation analysis was used to evaluate the correlation between MPO/HDL and NIHSS scores. The predictive value of MPO, HDL and MPO/HDL to AIS was evaluated by receiver operating characteristic curve (ROC). The level of MPO/HDL in patients with NIHSS score ≥ 4 was significantly higher than that in patients with NIHSS score < 4 (P < 0.001). MPO and MPO/HDL were positively correlated with NIHSS score (P < 0.001), while HDL was negatively correlated with NIHSS score (P < 0.001). During 90-day follow-up, multivariate Logistic regression analysis showed that increased MPO/HDL levels were associated with 90-day functional outcomes. ROC showed that compared with MPO and HDL, MPO/HDL had the highest predictive value for 90-day functional prognosis in patients with AIS (AUC = 0.9825). The level of serum MPO/HDL may be potential prognostic biomarker in AIS 90 days.

中文翻译：

---

髓过氧化物酶与高密度脂蛋白的比率：急性缺血性卒中患者严重程度和结局的潜在预测因子

髓过氧化物酶与高密度脂蛋白（MPO/HDL）的比值作为炎症和脂质代谢的新标志物，在心血管疾病领域已有报道。然而，MPO/HDL 对急性缺血性卒中（AIS）的影响尚不清楚。本研究的目的是探讨 MPO/HDL 水平对 AIS 患者的预后价值。本研究对 363 名诊断为 AIS 的患者进行了回顾性分析。中风严重程度通过美国国立卫生研究院中风量表（NIHSS）进行评估。入院后 90 天采用改良 Rankin 量表 (mRS) 评估短期功能结果。 Spearman相关分析用于评估MPO/HDL与NIHSS评分之间的相关性。通过受试者工作特征曲线（ROC）评估MPO、HDL和MPO/HDL对AIS的预测价值。 NIHSS评分≥4的患者MPO/HDL水平显着高于NIHSS评分<4的患者（P<0.001）。 MPO和MPO/HDL与NIHSS评分呈正相关（P < 0.001），而HDL与NIHSS评分呈负相关（P < 0.001）。在 90 天的随访期间，多变量 Logistic 回归分析显示，MPO/HDL 水平升高与 90 天的功能结果相关。 ROC显示，与MPO和HDL相比，MPO/HDL对AIS患者90天功能预后的预测价值最高（AUC = 0.9825）。血清 MPO/HDL 水平可能是 AIS 90 天的潜在预后生物标志物。