The striatum plays a crucial role in studying epilepsy, as it is involved in seizure generation and modulation of brain activity. To explore the complex interplay between the striatum and epilepsy, we engineered advanced microelectrode arrays (MEAs) specifically designed for precise monitoring of striatal electrophysiological activities in rats. These observations were made during and following seizure induction, particularly three and 7 days post-initial modeling. The modification of graphene oxide (GO)/poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS)/platinu-m nanoparticles (PtNPs) demonstrated a marked reduction in impedance (10.5 ± 1.1 kΩ), and maintained exceptional stability, with impedance levels remaining consistently low (23 kΩ) even 14 days post-implantation. As seizure intensity escalated, we observed a corresponding increase in neuronal firing rates and local field potential power, with a notable shift towards higher frequency peaks and augmented inter-channel correlation. Significantly, during the grand mal seizures, theta and alpha bands became the dominant frequencies in the local field potential. Compared to the normal group, the spike firing rates on day 3 and 7 post-modeling were significantly higher, accompanied by a decreased firing interval. Power in both delta and theta bands exhibited an increasing trend, correlating with the duration of epilepsy. These findings offer valuable insights into the dynamic processes of striatal neural activity during the initial and latent phases of temporal lobe epilepsy and contribute to our understanding of the neural mechanisms underpinning epilepsy.

中文翻译：

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利用 GO/PEDOT:PSS/PtNPs 增强的高稳定性微电极阵列研究癫痫引起的纹状体电生理学改变

纹状体在癫痫研究中起着至关重要的作用，因为它参与癫痫发作和大脑活动的调节。为了探索纹状体和癫痫之间复杂的相互作用，我们设计了先进的微电极阵列（MEA），专门用于精确监测大鼠纹状体电生理活动。这些观察是在癫痫发作诱导期间和之后进行的，特别是初始建模后 3 天和 7 天。氧化石墨烯（GO）/聚（3,4-乙烯二氧噻吩）：聚苯乙烯磺酸盐（PEDOT：PSS）/铂纳米粒子（PtNP）的改性表现出阻抗显着降低（10.5±1.1kΩ），并保持优异的稳定性，即使在植入后 14 天，阻抗水平也始终保持较低水平 (23 kΩ)。随着癫痫发作强度的增加，我们观察到神经元放电率和局部场电位功率相应增加，并显着转向更高的频率峰值和增强的通道间相关性。值得注意的是，在大发作期间，θ 和 α 频带成为局部场电位的主导频率。与正常组相比，建模后第3天和第7天的尖峰放电率显着升高，同时放电间隔缩短。 δ 和 θ 波段的功率均呈现增加趋势，与癫痫持续时间相关。这些发现为颞叶癫痫初期和潜伏期纹状体神经活动的动态过程提供了有价值的见解，并有助于我们理解癫痫的神经机制。