Post-COVID-19 condition (PCC) is associated with a host of psychopathological conditions including prominent anxiety symptoms. However, it is not known what effect anxious symptoms have on measures of well-being in individuals living with PCC. This study aims to evaluate anxiety’s association with measures of well-being in people with PCC.

This is a post hoc analysis utilizing data from a placebo-controlled, randomized, double-blind clinical trial assessing the effect of vortioxetine on cognitive impairment in individuals with PCC (NCT05047952). Baseline data with respect to anxiety and well-being were collected using the Generalized Anxiety Disorder Scale, 7-Item (GAD-7), and the World Health Organization (WHO) Well-Being Index, 5-Item (WHO-5), respectively. A generalized linear model (GLM) analysis on baseline GAD-7 and WHO-5 scores was conducted with age, sex, employment status, education level, previous major depressive disorder (MDD) diagnosis, and confirmed COVID-19 cases as covariates.

Data was analyzed in a sample of 144 participants (N = 144). After controlling for the aforementioned covariates, the results found that GAD-7 and WHO-5 scores had a significant negative correlation (β = −0.053, p = <0.001), signifying that increased anxiety had adverse effects on the overall well-being of individuals with PCC.

Herein, we observed a clinically meaningful level of anxiety in individuals with PCC. We also identified a robust correlation between anxiety in PCC and measures of general well-being. Our results require replication, providing the impetus for recommending screening and targeting anxious symptoms as a tactic to improve general well-being and outcomes in individuals with PCC.

COVID-19 后病症 (PCC) 与许多精神病理状况相关，包括明显的焦虑症状。然而，目前尚不清楚焦虑症状对 PCC 患者的幸福感有何影响。本研究旨在评估 PCC 患者的焦虑与幸福感的关系。

这是一项事后分析，利用安慰剂对照、随机、双盲临床试验的数据，评估沃替西汀对 PCC 个体认知障碍的影响 (NCT05047952)。使用广泛性焦虑症量表，7 项 (GAD-7) 和世界卫生组织 (WHO) 幸福指数，5 项 (WHO-5) 收集有关焦虑和幸福感的基线数据，分别。对基线 GAD-7 和 WHO-5 评分进行了广义线性模型 (GLM) 分析，以年龄、性别、就业状况、教育水平、既往重度抑郁症 (MDD) 诊断以及确诊的 COVID-19 病例作为协变量。

对 144 名参与者 ( N  = 144)的样本进行了数据分析。控制上述协变量后，结果发现 GAD-7 和 WHO-5 评分存在显着负相关（β = -0.053，p  = <0.001），表明焦虑增加对整体幸福感产生不利影响。患有 PCC 的个人。

在此，我们观察到 PCC 患者的焦虑水平具有临床意义。我们还发现 PCC 的焦虑与总体幸福感之间存在很强的相关性。我们的结果需要复制，为推荐筛查和针对焦虑症状作为改善 PCC 患者总体健康和预后的策略提供动力。