Chiral amines possessing a stereogenic carbon atom bearing three carbon substituents and one nitrogen substituent are challenging structural motifs to prepare enantioselectively. Now, such motifs have been accessed in high enantiopurities by asymmetric Cu-catalysed propargylic amination using sterically confined ligands.

中文翻译：

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铜催化不对称胺化

具有带有三个碳取代基和一个氮取代基的立体碳原子的手性胺对于对映选择性制备具有挑战性的结构基序。现在，通过使用空间限制的配体进行不对称铜催化的炔丙基胺化，已经获得了高对映体纯度的此类基序。