In mice, zygotic genome activation occurs at onset of the two-cell stage in embryonic development and coincides with the exit from totipotency. Our work shows that the transcription factor DUXBL participates in silencing part of the stage-specific two-cell-associated transcriptional program and is required for development to proceed.

中文翻译：

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小鼠全能性的退出由 DUXBL 控制

在小鼠中，合子基因组激活发生在胚胎发育的双细胞阶段开始时，并且与全能性的退出同时发生。我们的工作表明，转录因子 DUXBL 参与阶段特异性两细胞相关转录程序的沉默部分，并且是发育进行所需的。