The exact relationship between 3D chromatin interactions and enhancer function is unclear. By probing three-dimensional enhancer interactions in developing embryos, two studies now show nuanced dynamics in tissue-specific contexts and reveal how moderately increased enhancer–promoter interactions coincide with functionality.

中文翻译：

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胚胎发育过程中的增强子接触显示出多种相互作用模式，并且在基因激活后适度但显着的增加

3D 染色质相互作用与增强子功能之间的确切关系尚不清楚。通过探索发育中胚胎中的三维增强子相互作用，两项研究现在显示了组织特异性背景下的微妙动态，并揭示了适度增加的增强子-启动子相互作用如何与功能相一致。