Abstract

The effect of stevia leaf extract, saccharinate, and cyclamate in various dosages on the glycogen content of blood leukocytes in C57BL/6 mice as a necessary substrate for the realization of phagocytosis was studied. An increase in glycogen content was found in all experimental groups treated with sweeteners at a dosage of 10 mg/g of body weight. The effect of sweeteners on the differential leukocyte counts was found only in mice receiving the stevia leaf extract at a dosage of 10 mg/g of body weight manifested as an increase neutrophil-to-lymphocyte ratio (NLR). The data obtained expand our understanding of the metabolism of sugar substitutes in an organism and their influence on physiological systems, in particular, the hematopoietic and immune systems.

中文翻译：

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不同甜味剂对C57BL/6小鼠血液白细胞糖原含量及白细胞分类计数的影响

摘要

研究了不同剂量的甜叶菊叶提取物、糖精酸盐和甜蜜素对C57BL/6小鼠血液白细胞糖原含量的影响，作为实现吞噬作用的必需底物。在使用剂量为 10 毫克/克体重的甜味剂处理的所有实验组中，发现糖原含量有所增加。仅在接受剂量为 10 毫克/克体重的甜叶菊叶提取物的小鼠中发现甜味剂对白细胞计数差异的影响，表现为中性粒细胞与淋巴细胞比率 (NLR) 的增加。获得的数据扩展了我们对生物体中糖替代品的代谢及其对生理系统，特别是造血和免疫系统的影响的理解。