With the wide use of antibiotics in clinical, agricultural, and industrial settings, many bacteria have developed antimicrobial resistance rapidly over the past several decades. It has been estimated that antimicrobial resistance currently causes 700,000 deaths per year, and it will cause a 2%–3.5% reduction in Gross Domestic Product by 2050 (1). Therefore, the World Health Organization has declared antimicrobial resistance to be an important threat to human health and ecological safety (2).

中文翻译：

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吩嗪产生的群体感应调节增强了铜绿假单胞菌对环丙沙星的耐药性

随着抗生素在临床、农业和工业环境中的广泛使用，许多细菌在过去几十年中迅速产生了抗菌素耐药性。据估计，目前抗菌药物耐药性每年导致 70 万人死亡，到 2050 年将导致国内生产总值减少 2%–3.5% (1)。因此，世界卫生组织宣布抗菌素耐药性是对人类健康和生态安全的重要威胁(2)。