Alzheimer's disease (AD) levels have increased globally, which is considered the sixth reason for deaths. So, a requirement exists for economic and quantitative methods to follow up the gradual progression of AD. The current study presents a simulation for a non‐irradiated, safe, wearable, and noninvasive mobile approach for detecting the progression of Alzheimer's brain atrophy using the optical diffusion technique and for investigating the difference between the normal and the diseased brain. The virtual study was accomplished using COMSOL Multiphysics. The simulated head is implemented as the following: scalp, skull, cerebrospinal fluid, gray matter, and white matter. The optical properties of the heterogeneous tissue are observed using the fluence rate after irradiating the head with different wavelengths (630, 700, 810, 915, and 1000 nm) of lasers. Two assessment techniques were applied to evaluate the brain atrophy measurements; the first technique was an array of photodetectors, which were lined at the head posterior, while a matrix of photodetectors was applied over the head surface in the second technique. The results show that the surface photodetectors approach differentiates the normal from AD brains without measuring the brain atrophy percentages by applying 630 nm. The array of photodetectors distinguishes normal from AD brains without detecting the brain atrophy percentages when the wavelengths 630, 700, and 810 nm were applied. The line detector at 1000 nm evaluates the brain atrophy percentages with AD. The future explores applying those techniques in vivo and analyzing the information by the spectrometer for extensively safer early detection of neural disorders.

中文翻译：

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基于使用替代激光波长的光注量率测量的阿尔茨海默病进展检测

阿尔茨海默病（AD）的发病率在全球范围内有所增加，这被认为是第六大死亡原因。因此，需要经济和定量方法来跟踪 AD 的逐步进展。目前的研究提出了一种非辐射、安全、可穿戴和非侵入性移动方法的模拟，用于使用光学扩散技术检测阿尔茨海默氏症脑萎缩的进展，并研究正常大脑和患病大脑之间的差异。虚拟研究是使用 COMSOL Multiphysics 完成的。模拟头部实现如下：头皮、头骨、脑脊液、灰质和白质。使用不同波长（630、700、810、915和1000 nm）激光照射头部后的注量率观察异质组织的光学特性。应用两种评估技术来评估脑萎缩测量结果；第一种技术是在头部后部排列光电探测器阵列，而第二种技术则在头部表面应用光电探测器矩阵。结果表明，表面光电探测器方法可以区分正常大脑和 AD 大脑，而无需通过应用 630 nm 测量脑萎缩百分比。当应用波长 630、700 和 810 nm 时，光电探测器阵列可以区分正常大脑和 AD 大脑，而无需检测脑萎缩百分比。 1000 nm 的线检测器可评估 AD 的脑萎缩百分比。未来将探索在体内应用这些技术并通过光谱仪分析信息，以更安全地早期检测神经疾病。