Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain,Autophagy

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Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain
Autophagy ( IF 13.3 ) Pub Date : 2024-03-24 , DOI: 10.1080/15548627.2024.2330038
Su Fu ₁ , Haojie Sun _{1,

2,

3} , Jiaxin Wang _{1,

2} , Shuaixin Gao _{4,

5} , Liu Zhu ₆ , Kun Cui _{1,

2} , Shimeng Liu ₇ , Xuetao Qi _{1,

2} , Rui Guan _{1,

2} , Xiaocen Fan _{1,

2} , Qingying Liu _{1,

2} , Wen Chen _{1,

2} , Li Su _{1,

2} , Shuang Cui _{1,

2} , Feifei Liao _{1,

2} , Fengyu Liu _{1,

2} , Catherine C L Wong ₄ , Ming Yi _{1,

2} , You Wan _{1,

2,

8}

Affiliation

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory for Neuroscience, Ministry of Education and National Health Commission, Peking University, Beijing, China
UCL School of Pharmacy, University College London, London, UK
Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
Human Nutrition Program, Department of Human Sciences & James Comprehensive Cancer Center, 309 Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Laboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University, Beijing, China
Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, P.R. China

A large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanism...

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