Malformations of cortical development (MCDs) are caused by abnormal neuronal migration processes during the fetal period and are a major cause of intractable epilepsy in infancy. However, the timing of hyperexcitability or epileptogenesis in MCDs remains unclear. To identify the early developmental changes in the brain of the MCD rat model, which exhibits increased seizure susceptibility during infancy (P12–15), we analyzed the pathological changes in the brains of MCD model rats during the neonatal period and tested NMDA-induced seizure susceptibility.

中文翻译：

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皮质发育畸形大鼠模型的早期发育变化：神经元迁移异常和对 NMDA 诱导的兴奋性毒性损伤的反应改变

皮质发育畸形（MCD）是由胎儿期神经元迁移过程异常引起的，是婴儿期难治性癫痫的主要原因。然而，MCD 中过度兴奋或癫痫发生的时间仍不清楚。为了确定 MCD 大鼠模型大脑的早期发育变化（在婴儿期（P12-15）表现出癫痫易感性增加），我们分析了 MCD 模型大鼠在新生儿期的大脑病理变化，并测试了 NMDA 诱导的癫痫发作易感性。