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Association between polymorphisms and atopic dermatitis susceptibility: A systematic review and meta-analysis
Gene ( IF 3.5 ) Pub Date : 2024-03-19 , DOI: 10.1016/j.gene.2024.148397 Yunxia Huang , Wei Zhou , Shunan Liu , Dan Zeng , Weikang Zhou
Gene ( IF 3.5 ) Pub Date : 2024-03-19 , DOI: 10.1016/j.gene.2024.148397 Yunxia Huang , Wei Zhou , Shunan Liu , Dan Zeng , Weikang Zhou
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease that is closely linked to genetic factors. Previous studies have revealed numerous single nucleotide polymorphisms (SNPs) that been related to susceptibility to AD; however, the results are conflicting. Therefore, a meta-analysis was conducted to assess the associations of these polymorphisms and AD risk. PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure databases were retrieved to identify eligible studies, with selected polymorphisms being reported in a minimum of three separate studies. The Newcastle-Ottawa Scale (NOS) was used to evaluate study quality. Review Manager 5.3 and STATA 14.0 were used to perform the meta-analysis. After screening, 64 studies involving 13 genes (24 SNPs) were selected for inclusion in the meta-analysis. Nine SNPs were positively correlated with AD susceptibility [filaggrin () R501X, 2282del4, chromosome 11q13.5 rs7927894, interleukin rs2275913, –137 G/C, Toll-like receptor 2 () rs5743708, A-16934 T, serine protease inhibitor Kazal type-5 () Asn368Ser, interferon-γ () T874A] and one was negatively associated with AD susceptibility ( –1098 T/G). The 14 remaining SNPs were not significantly associated with AD susceptibility. Nine SNPs that may be risk factors and one SNP that may be a protective factor for AD were identified, providing a reference for AD prediction, prevention, and therapy.
更新日期：2024-03-19
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