Skin tissue is a kind of complex biological material abundant with fibers. A new constitutive model, relating macroscopic responses with microstructural fiber configuration alteration, is developed to investigate the stress softening behaviors of skin tissue observed during cyclic loading–unloading tests. Two influential factors are introduced to describe the impact of fiber configuration change and stretch-induced damage. The present model achieves good agreement between predicted stress distribution of human skin and corresponding ex vivo experimental data obtained from the literature, affirming its capability to effectively capture the characteristic softening behaviors of human skin under cyclic loading conditions.

皮肤组织是一种富含纤维的复杂生物材料。开发了一种新的本构模型，将宏观响应与微观结构纤维构型变化联系起来，用于研究循环加载-卸载测试期间观察到的皮肤组织的应力软化行为。引入两个影响因素来描述纤维构型变化和拉伸引起的损伤的影响。该模型在预测的人体皮肤应力分布与从文献中获得的相应离体实验数据之间取得了良好的一致性，证实了其能够有效捕捉循环加载条件下人体皮肤特征软化行为的能力。