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Probing the Dynamic Landscape: From Static to Time-Resolved X-Ray Absorption Spectroscopy to Investigate Copper Redox Chemistry in Neurodegenerative Disorders
ChemPlusChem ( IF 3.4 ) Pub Date : 2024-03-25 , DOI: 10.1002/cplu.202300712
Emiliano De Santis 1 , Stefania Alleva 2 , Velia Minicozzi 3 , Francesco Stellato 4
Affiliation  

Time-resolved X-ray Absorption Spectroscopy will be the camcorder for capturing atomic resolution molecular movies. The key players in these movies are Cu(I) and Cu(II) ions, which, when complexed with proteins and peptides associated with neurodegenerative diseases, can act as redox agents with potential pathogenic implications.

中文翻译:

探索动态景观:从静态到时间分辨 X 射线吸收光谱研究神经退行性疾病中的铜氧化还原化学

时间分辨X射线吸收光谱仪将成为捕捉原子分辨率分子电影的摄像机。这些电影中的关键角色是 Cu(I) 和 Cu(II) 离子,当它们与与神经退行性疾病相关的蛋白质和肽复合时,可以充当具有潜在致病影响的氧化还原剂。
更新日期:2024-03-25
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