In recent years, the design and synthesis of Janus hydrogels have witnessed a thriving development, overcoming the limitations of single-performance materials and expanding their potential applications in tissue engineering and regenerative medicine. Janus hydrogels, with their exceptional mechanical properties and excellent biocompatibility, have emerged as promising candidates for various biomedical applications, including tissue engineering and regenerative therapies. In this review, we present the latest progress in the synthesis of Janus hydrogels using commonly employed preparation methods. We elucidate the surface and interface interactions of these hydrogels and discuss the enhanced properties bestowed by the unique “Janus” structure in biomaterials. Additionally, we explore the applications of Janus hydrogels in facilitating regenerative therapies, such as drug delivery, wound healing, tissue engineering, and biosensing. Furthermore, we analyze the challenges and future trends associated with the utilization of Janus hydrogels in biomedical applications.

中文翻译：

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Janus 水凝胶：融合组织工程的边界，以增强生物材料和再生疗法

近年来，Janus水凝胶的设计和合成得到了蓬勃发展，克服了单一性能材料的局限性，扩大了其在组织工程和再生医学中的潜在应用。 Janus水凝胶具有卓越的机械性能和出色的生物相容性，已成为各种生物医学应用（包括组织工程和再生疗法）的有前途的候选者。在这篇综述中，我们介绍了使用常用制备方法合成 Janus 水凝胶的最新进展。我们阐明了这些水凝胶的表面和界面相互作用，并讨论了生物材料中独特的“Janus”结构所赋予的增强性能。此外，我们还探索了 Janus 水凝胶在促进再生疗法方面的应用，例如药物输送、伤口愈合、组织工程和生物传感。此外，我们分析了 Janus 水凝胶在生物医学应用中的应用所面临的挑战和未来趋势。