Polymeric micelle systems for drug delivery, monitor and chemotherapy have gained significant attention, and reductive polymeric micelle systems have become particularly attractive due to their controlled release behavior without additional assistance. However, there are challenges in accurately controlling drug and probe release from the nanoparticles and determining the loading content of drug and probe. To address these issues, we have developed a reduction-responsive Pt(IV) prodrug-based polymeric delivery system that can be dynamically monitored using aggregation-induced emission luminogens (AIE) based bioprobes. These polymeric micelle can self-assemble into nanoparticles and release both bio-active Pt(II) drug and bio-probe upon reduction activation. TPE molecules released in the inner endo/lysosomal microenvironment aggregate and fluoresce upon irradiation, thus allowing real-time tracking of drug biodistribution without additional contrast agents. Advantages of this system include position-specific chemical bond cleavage, control of platinum content, and monitoring of drug reduction and biodistribution.

中文翻译：

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用于监测和化疗的还原性前药和 AIE 共聚物纳米颗粒

用于药物输送、监测和化疗的聚合物胶束系统已经引起了极大的关注，而还原性聚合物胶束系统由于其无需额外辅助的控释行为而变得特别有吸引力。然而，准确控制药物和探针从纳米颗粒中的释放以及确定药物和探针的负载含量仍存在挑战。为了解决这些问题，我们开发了一种基于还原响应 Pt(IV) 前药的聚合物递送系统，可以使用基于聚集诱导发射发光体 (AIE) 的生物探针进行动态监测。这些聚合物胶束可以自组装成纳米颗粒，并在还原激活后释放生物活性 Pt(II) 药物和生物探针。在内内/溶酶体微环境中释放的 TPE 分子在照射下聚集并发出荧光，从而无需额外的造影剂即可实时跟踪药物的生物分布。该系统的优点包括特定位置的化学键断裂、铂含量的控制以及药物还原和生物分布的监测。