Obesity, a prevalent disease associated with numerous chronic conditions, including hyperlipidemia, hyperglycemia, diabetes, and metabolic syndrome, remains a major global health challenge. This study investigated the potential of green tea (GT), fermented tea (FT), and γ-aminobutyric acid (GABA) tea (GBT), which are rich in phytonutrients and polyphenols, for the management of obesity. Using a high-fat diet-induced obese mouse model (C57BL/6N), we explored the effect of these teas on various obesity-related parameters. The mice were categorized into five groups: normal diet with water, high-fat diet with water, and high-fat diet supplemented with GT, FT, or GBT. Over 13 weeks, we monitored body weight, perirenal and liver fat, adipocyte lipid accumulation, and key metabolic indicators, such as serum cholesterol, leptin, insulin, and fasting blood glucose. These teas contain beneficial phytochemicals such as GABA, theanine, and caffeine, and have demonstrated an enhanced antioxidant capacity, which increases the scavenging of free radicals and may reduce oxidative stress. The animal study indicated a decrease in feeding efficiency and significant reductions in body weight liver fat, epididymal fat, and perirenal fat, as well as in adipocyte lipid accumulation. Additionally, notable improvements were observed in metabolic health indicators, including reductions in serum cholesterol, leptin, insulin, and fasting blood glucose levels. Our findings revealed that GT, FT, or GBT significantly counteracted the negative effects of a high-fat diet, suggesting their potential in combating obesity and related metabolic disorders.

中文翻译：

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绿茶、发酵茶和γ-氨基丁酸茶在高脂饮食诱导的小鼠模型中的抗肥胖作用的比较分析

肥胖是一种与高脂血症、高血糖、糖尿病和代谢综合征等多种慢性疾病相关的普遍疾病，仍然是全球主要的健康挑战。本研究调查了富含植物营养素和多酚的绿茶 (GT)、发酵茶 (FT) 和 γ-氨基丁酸 (GABA) 茶 (GBT) 在控制肥胖方面的潜力。使用高脂肪饮食诱导的肥胖小鼠模型（C57BL/6N），我们探讨了这些茶对各种肥胖相关参数的影响。将小鼠分为五组：正常饮食（含水）、高脂饮食（含水）、高脂饮食添加 GT、FT 或 GBT。在 13 周的时间里，我们监测了体重、肾周和肝脏脂肪、脂肪细胞脂质积累以及关键代谢指标，如血清胆固醇、瘦素、胰岛素和空腹血糖。这些茶含有有益的植物化学物质，如 GABA、茶氨酸和咖啡因，并具有增强的抗氧化能力，可增加自由基的清除并可能减少氧化应激。动物研究表明，饲养效率下降，体重肝脏脂肪、附睾脂肪和肾周脂肪以及脂肪细胞脂质积累显着减少。此外，代谢健康指标也显着改善，包括血清胆固醇、瘦素、胰岛素和空腹血糖水平降低。我们的研究结果表明，GT、FT 或 GBT 可以显着抵消高脂肪饮食的负面影响，这表明它们在对抗肥胖和相关代谢紊乱方面具有潜力。