Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and reactive oxygen species (ROS) metabolism, including the XC−/GSH/GPX4 system, ACSL4/LPCAT3/15-LOX and FSP1/CoQ10/NAD(P)H pathways, and investigate the correlation between ferroptosis and LncRNA in BC to determine possible biomarkers related to ferroptosis.

中文翻译：

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铁死亡和铁死亡相关的长非编码RNA在乳腺癌中的作用

铁死亡是一种肿瘤治疗策略，是一种受调节的细胞死亡，其特征是铁依赖性脂质过氧化物 (LPO) 积累增加。肿瘤相关长非编码RNA（lncRNA）与传统抗癌药物或放射治疗相结合，可以提高癌症的疗效并降低死亡率。研究铁死亡相关 lncRNA 的作用可能有助于制定乳腺癌 (BC) 新的治疗方案。在此，我们简要讨论铁死亡涉及铁和活性氧（ROS）代谢的基因和途径，包括XC−/GSH/GPX4系统、ACSL4/LPCAT3/15-LOX和FSP1/CoQ10/NAD(P)H途径，并研究 BC 中铁死亡和 LncRNA 之间的相关性，以确定与铁死亡相关的可能生物标志物。