: Depression is a common mental illness that damages the life and health of patients and causes economic burden, and HPA (hypothalamic-pituitary-adrenal) axis dysfunction is considered to be one of the important factors leading to depression. In this case, it is essential to explore possible treatment methods by using natural compounds with HPA axis regulating and antidepressant effects. However, no one has reviewed it so far. Therefore, the purpose of this review is to systematically sort out the related natural products that play an antidepressant role by regulating the function of the HPA axis. Natural products are divided into flavonoids, polyphenols, terpenoids, saponins, polysaccharides and so on according to their chemical structures, which play a variety of biological activities such as regulating the HPA axis, anti-inflammation and neuroprotection. These effects may provide a useful reference for the potential treatment of depression so as to develop new antidepressants.

中文翻译：

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天然草药化合物通过下丘脑-垂体-肾上腺轴调节发挥抗抑郁作用

：抑郁症是一种常见的精神疾病，损害患者的生命健康并造成经济负担，而HPA（下丘脑-垂体-肾上腺）轴功能障碍被认为是导致抑郁症的重要因素之一。在这种情况下，有必要探索利用具有HPA轴调节和抗抑郁作用的天然化合物的可能治疗方法。然而，到目前为止，还没有人对其进行过审查。因此，本综述的目的是系统梳理通过调节HPA轴功能发挥抗抑郁作用的相关天然产物。天然产物根据化学结构分为黄酮类、多酚类、萜类、皂苷类、多糖类等，发挥调节HPA轴、抗炎、神经保护等多种生物活性。这些作用可能为抑郁症的潜在治疗提供有用的参考，从而开发新的抗抑郁药物。