: Since hydroxyapatite (HAp) is an important constituent of bone and teeth, it has excellent biocompatibility and bioactivity, good osteoconductive effects and the ability to induce bone formation as a material for bone or tooth repair and replacement. At present, widely used HAp microspheres have some characteristics, such as large specific surface area, light mass, good injection properties, good fluidity, and low aggregation ability, but they are difficult to really meet the biological and clinical needs due to their own mechanical property defects, such as low strength, brittleness, and poor plasticity. Based on the current research status of HAp microspheres, we summarize the research progress of various types of composite microspheres, including inorganic materials, natural polymer materials and synthetic polymer materials, and further analyze the advantages of HAp composite microspheres loaded with drug molecules, proteins and bioactive factors, so as to explore the development prospect of HAp composite microspheres as scaffolds for constructing sustained release systems. It provides a theoretical basis and research direction to prepare HAp composite micro-spheres with superior comprehensive properties so that they can be better applied in bone tissue regeneration and tooth regeneration engineering.

中文翻译：

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复合或改性羟基磷灰石微球作为骨和牙齿组织工程的药物输送载体

：由于羟基磷灰石（HAp）是骨骼和牙齿的重要组成部分，因此具有优异的生物相容性和生物活性，良好的骨传导作用和诱导骨形成的能力，作为骨骼或牙齿修复和替换的材料。目前广泛应用的HAp微球具有比表面积大、质量轻、注射性能好、流动性好、聚集能力低等特点，但由于其自身的力学性能，很难真正满足生物学和临床的需求。强度低、脆性、塑性差等性能缺陷。基于HAp微球的研究现状，总结了无机材料、天然高分子材料和合成高分子材料等各类复合微球的研究进展，并进一步分析了负载药物分子、蛋白质和药物分子的HAp复合微球的优势。生物活性因子，探讨HAp复合微球作为支架构建缓释系统的发展前景。为制备综合性能优越的HAp复合微球，使其更好地应用于骨组织再生和牙齿再生工程提供了理论基础和研究方向。