Depression is a common psychiatric disorder among individuals with Huntington’s disease (HD). Depression in HD and major depressive disorder appear to have different pathophysiological mechanisms. Despite the unique pathophysiology, the treatment of depression in HD is based on data from the treatment of major depressive disorder in the general population. The objective of this systematic review was to conduct a comprehensive evaluation of the available evidence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Studies on the treatment of depression in HD were identified by searching MEDLINE, Embase, and PsycInfo. The initial search yielded 2,771 records, 41 of which were ultimately included. There were 19 case reports, seven case series, three cross-sectional studies, one qualitative study, nine nonrandomized studies, and two randomized trials among the included studies. The most common assessment tools were the Hospital Anxiety and Depression Scale (N=8), the Beck Depression Inventory (N=6), and the Hamilton Depression Rating Scale (N=6). Only 59% of the included studies assessed depressive symptoms with a scoring system. The pharmacological options for the treatment of depression included antidepressants and antipsychotics. Nonpharmacological approaches were multidisciplinary rehabilitation, psychotherapy, and neurostimulation. Limited evidence on the treatment of depression in HD was available, and this literature consisted mainly of case reports and case series. This systematic review highlights the knowledge gap and the pressing need for HD-specific research to determine the efficacy of treatment approaches for depression in HD.

抑郁症是亨廷顿舞蹈病 (HD) 患者中常见的精神疾病。 HD 中的抑郁症和重度抑郁症似乎具有不同的病理生理机制。尽管病理生理学独特，HD 抑郁症的治疗还是基于普通人群重度抑郁症的治疗数据。本次系统评价的目的是对现有证据进行全面评估。遵循系统评价和荟萃分析指南的首选报告项目。通过搜索 MEDLINE、Embase 和 PsycInfo 找到了有关 HD 抑郁症治疗的研究。最初的搜索产生了 2,771 条记录，最终收录了其中 41 条。纳入的研究中有19个病例报告、7个病例系列、3个横断面研究、1个定性研究、9个非随机研究和2个随机试验。最常见的评估工具是医院焦虑和抑郁量表（N=8）、贝克抑郁量表（N=6）和汉密尔顿抑郁量表（N=6）。只有 59% 的纳入研究使用评分系统评估抑郁症状。治疗抑郁症的药物选择包括抗抑郁药和抗精神病药。非药物治疗方法包括多学科康复、心理治疗和神经刺激。关于 HD 抑郁症治疗的可用证据有限，该文献主要包括病例报告和病例系列。本系统综述强调了 HD 特定研究的知识差距和迫切需要，以确定 HD 抑郁症治疗方法的疗效。