Ovarian cancer presents a substantial challenge due to its high mortality and recurrence rates among gynecological tumors. Existing clinical chemotherapy treatments are notably limited by drug resistance and systemic toxic side effects caused by off target drugs. Sonodynamic therapy (SDT) has emerged as a promising approach in cancer treatment, motivating researchers to explore synergistic combinations with other therapies for enhanced efficacy. In this study, we developed magnetic sonodynamic nanorobot (Fe3O4@SiO2-Ce6, FSC) by applying a SiO2 coating onto Fe3O4 nanoparticle, followed by coupling with the sonosensitizer Ce6. The magnetic FSC nanorobot collectives could gather at fixed point and actively move to target site regulated by magnetic field. In vitro experiments revealed that the magnetic FSC nanorobot collectives enabled directional navigation to the tumor cell area under guidance. Furthermore, under low-intensity ultrasonic stimulation, FSC nanorobot collectives mediated sonodynamic therapy exhibited remarkable anti-tumor performance. These findings suggest that magnetically actuated sonodynamic nanorobot collectives hold promising potential for application in target cancer therapy.

中文翻译：

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用于增强卵巢癌治疗的磁驱动声动力纳米机器人集体

卵巢癌由于其在妇科肿瘤中的高死亡率和复发率而提出了巨大的挑战。现有的临床化疗治疗明显受到耐药性和脱靶药物引起的全身毒副作用的限制。声动力疗法 (SDT) 已成为一种有前景的癌症治疗方法，促使研究人员探索与其他疗法的协同组合以增强疗效。在这项研究中，我们开发了磁声动力纳米机器人（Fe3氧4@SiO22-Ce6, FSC) 通过应用 SiO2镀在铁上3氧4纳米粒子，然后与声敏剂 Ce6 耦合。磁性FSC纳米机器人集体可以定点聚集，并在磁场调节下主动移动到目标地点。体外实验表明，磁性 FSC 纳米机器人集体能够在引导下定向导航到肿瘤细胞区域。此外，在低强度超声刺激下，FSC纳米机器人集体介导的声动力疗法表现出显着的抗肿瘤性能。这些发现表明磁驱动声动力纳米机器人集体在癌症靶向治疗中具有广阔的应用前景。