Abstract

Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with increasing morbidity and mortality. Exploring the factors affecting colorectal carcinogenesis and controlling its occurrence at its root is as important as studying post-cancer treatment and management. Establishing ideal animal models of CRC is crucial, which can occur through various pathways, such as adenoma-carcinoma sequence, inflammation-induced carcinogenesis, serrated polyp pathway and de-novo pathway. This article aims to categorize the existing well-established CRC animal models based on different carcinogenesis pathways, and to describe their mechanisms, methods, advantages and limitations using domestic and international literature sources. This will provide suggestions for the selection of animal models in early-stage CRC research.

中文翻译：

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不同癌变途径的结直肠癌动物模型研究进展

摘要

结直肠癌（CRC）是胃肠道常见的恶性肿瘤，其发病率和死亡率不断增加。探索影响结直肠癌发生的因素并从根源上控制其发生与研究癌后治疗和管理同样重要。建立理想的CRC动物模型至关重要，它可以通过多种途径发生，如腺瘤-癌序列、炎症诱发癌变、锯齿状息肉途径和从头途径。本文旨在根据不同的致癌途径对现有成熟的结直肠癌动物模型进行分类，并利用国内外文献描述其机制、方法、优点和局限性。这将为早期结直肠癌研究中动物模型的选择提供建议。