ObjectivesSevere polyhydramnios during pregnancy may be associated with long‐term lithium use and presents considerable challenges. This complication, which has been linked to induced nephrogenic diabetes insipidus (NDI), underscores the necessity for cautious management of pregnant women with bipolar disorder. This case report aims to elucidate the relationship between long‐term lithium use, pregnancy, and the development of severe polyhydramnios, emphasizing the importance of diagnosing NDI in order to prevent obstetric and neonatal complications.MethodsWe present the case of a 42‐year‐old primigravida undergoing long‐term lithium treatment for bipolar disorder type I, who developed severe polyhydramnios at 34 weeks of gestation. Clinical data including obstetric monitoring and neonatal outcomes were analyzed.ResultsThis case emphasizes the need for heightened awareness and proactive measures to mitigate the risk associated with lithium treatment during pregnancy. Close monitoring and timely interventions are essential to ensure optimal outcomes for both mother and fetus.ConclusionsOur article puts forth the hypothesis that there is a link between lithium use during pregnancy and the occurrence of polyhydramnios and Nephrogenic Diabetes Insipidus (NDI), which may lead to severe obstetric and neonatal complications. This case report contributes to the limited literature on the subject and gives doctors practical advice that may help them make a better risk‐benefit analysis. Further research is warranted in order to refine risk assessment protocols and management strategies in this complex clinical scenario.

中文翻译：

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长期服用锂剂导致妊娠严重羊水过多1例

目的怀孕期间严重羊水过多可能与长期使用锂有关，并带来相当大的挑战。这种并发症与诱发性肾性尿崩症（NDI）有关，强调了对患有双相情感障碍的孕妇进行谨慎管理的必要性。本病例报告旨在阐明长期使用锂、妊娠和严重羊水过多之间的关系，强调诊断 NDI 以预防产科和新生儿并发症的重要性。方法我们介绍了一名 42 岁女性的病例因 I 型双相情感障碍接受长期锂盐治疗的初产妇，在妊娠 34 周时出现严重羊水过多。对包括产科监测和新生儿结局在内的临床数据进行了分析。结果该案例强调需要提高认识并采取积极措施，以减轻与妊娠期间锂治疗相关的风险。密切监测和及时干预对于确保母亲和胎儿获得最佳结果至关重要。结论我们的文章提出了这样的假设：怀孕期间使用锂与羊水过多和肾性尿崩症 (NDI) 的发生之间存在联系，这可能会导致严重的产科和新生儿并发症。本病例报告对有关该主题的有限文献做出了贡献，并为医生提供了实用建议，可以帮助他们做出更好的风险收益分析。需要进一步研究，以完善这种复杂临床情况下的风险评估方案和管理策略。