A novel methodology for investigating the behavior of nanoparticles in their mixtures in aqueous high-ionic strength conditions is presented in this work. Our approach utilizes Taylor dispersion analysis in capillaries connected to inductively coupled plasma mass spectrometry (ICP-MS) to probe metal-derived nanoparticles. This methodology simultaneously distinguishes between different kinds of nanoparticles and accurately determines their essential parameters, such as hydrodynamic size, diffusion coefficient, and elemental composition. Moreover, the isotope-specific ICP-MS detection allows for unique targeting of the fate of isotopically enriched nanoparticles. The complexity of our methodology opens the way for studying barely explored areas of interparticle interactions or unequivocal characterization of one type of nanoparticle in complex mixtures without any need for calibration as well as labor-consuming sample preparation.

中文翻译：

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通过泰勒色散分析与电感耦合等离子体质谱联用表征混合物中的纳米粒子

这项工作提出了一种研究纳米粒子在其混合物中在水性高离子强度条件下行为的新方法。我们的方法利用与电感耦合等离子体质谱 (ICP-MS) 连接的毛细管中的泰勒色散分析来探测金属衍生的纳米粒子。该方法同时区分不同种类的纳米粒子，并准确确定其基本参数，例如流体动力学尺寸、扩散系数和元素组成。此外，同位素特异性 ICP-MS 检测可以对同位素富集纳米颗粒的命运进行独特的定位。我们方法的复杂性为研究几乎没有探索过的颗粒间相互作用领域或复杂混合物中一种纳米颗粒的明确表征开辟了道路，而无需任何校准以及耗时的样品制备。