In this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents the systemic concentrations of volatile organic compounds (VOCs) – providing clinically relevant information about the human health. This is achieved via the development of a CO-triggered breath sampling system, which collected alveolar breath over several minutes in sterile and inert containers. A real-time mass spectrometer is coupled to serve as a reference device for calibration measurements and subsequent breath analysis. The new sensor system provided a 3σ detection limit of 8.3 ppbV and an NNEA of 1.4E-9 WcmHz. In terms of the performed breath analysis measurements, 12 out of 13 fell within the error margin of the photoacoustic measurement system, demonstrating the reliability of the measurements in the field.

中文翻译：

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一种廉价的基于 UV-LED 光声的实时传感器系统检测呼出的微量丙酮

在这项研究中，我们提出了一种基于 UV-LED 光声光谱的低成本呼吸丙酮分析系统。我们考虑了呼气的潮气末阶段，它代表了挥发性有机化合物 (VOC) 的全身浓度，提供了有关人类健康的临床相关信息。这是通过开发一氧化碳触发的呼吸采样系统来实现的，该系统在无菌和惰性容器中在几分钟内收集肺泡呼吸。连接实时质谱仪作为校准测量和后续呼吸分析的参考设备。新传感器系统的 3σ 检测限为 8.3 ppbV，NNEA 为 1.4E-9 WcmHz。就进行的呼吸分析测量而言，13 次中有 12 次落在光声测量系统的误差范围内，证明了现场测量的可靠性。