Mitochondria and their related genes (MTRGs) are pivotal in the tumour microenvironment (TME) of cervical cancer, influencing prognosis and treatment response. This study developed a prognostic model using MTRGs to predict overall survival (OS) in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), aiming for personalized therapy. Analysing 14 MTRGs like ISCU and NDUFA11 through techniques such as univariate Cox regression, we found that a low mitochondrial (MT) score is associated with better survival, while a high MT score predicts poorer outcomes. The TME score, particularly influenced by CD8 T cells, also correlates with prognosis, with a high score indicating favourable outcomes. The interplay between MT and TME subtypes revealed that the best prognosis is seen in patients with a low MT and high TME score. Our findings highlight the role of MTRGs as potential biomarkers and therapeutic targets in cervical cancer, offering a novel approach to improving patient outcomes through a more nuanced understanding of mitochondrial function and immune interactions within the TME. This model presents a promising avenue for enhancing the precision of prognostic assessments in CESC.

中文翻译：

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CESC单细胞验证中用于预测预后和评估肿瘤微环境的新型线粒体相关核心基因特征

线粒体及其相关基因（MTRG）在宫颈癌的肿瘤微环境（TME）中至关重要，影响预后和治疗反应。本研究开发了一种预后模型，利用 MTRG 来预测宫颈鳞状细胞癌和宫颈内膜腺癌 (CESC) 的总生存期 (OS)，旨在实现个性化治疗。通过单变量 Cox 回归等技术分析 ISCU 和 NDUFA11 等 14 个 MTRG，我们发现线粒体 (MT) 评分低与较好的生存率相关，而 MT 评分高则预示预后较差。 TME 评分（尤其受 CD8 T 细胞影响）也与预后相关，高评分表明预后良好。 MT 和 TME 亚型之间的相互作用表明，MT 低且 TME 评分高的患者预后最好。我们的研究结果强调了 MTRG 作为宫颈癌潜在生物标志物和治疗靶点的作用，通过更细致地了解 TME 内的线粒体功能和免疫相互作用，提供了一种改善患者预后的新方法。该模型为提高 CESC 预后评估的准确性提供了一条有前途的途径。