ObjectiveThe OpenVigil database can be used to assess medications that may cause supraventricular tachycardia (SVT) and to produce a reference for their safe use in clinical settings.MethodsWe analyzed first-quarter data from 2004 to 2023, obtained by searching the OpenVigil database using the keyword “supraventricular tachycardia.” Trade names and generic names were obtained by querying the RxNav database, and the proportions were summarized. The proportionate reporting ratio (PRR), reporting odds ratio, and chi-square values were also summarized. We created Asahi diagrams and set the screening criteria to drug events ≥30, PRR >2, and chi-square >4. Outcomes were evaluated using the Side Effect Resource database, several scientific literature databases, and the Hangzhou Yiyao Rational Medication System.ResultsA total of 2435 distinct medications were found to induce SVT between the first quarter of 2004 and 2023, leading to 22,375 documented adverse events related to SVT. Further investigation revealed that salbutamol, paroxetine, formoterol, paclitaxel, venlafaxine, and theophylline were most likely to cause SVT.ConclusionWe conducted signal mining of adverse drug events using the OpenVigil database and evaluated the six drugs most likely to cause SVT. The results of this research can serve as a drug safety reference in the clinic.

中文翻译：

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与室上性心动过速风险相关的药物：使用 OpenVigil 数据库进行分析

目的OpenVigil数据库可用于评估可能引起室上性心动过速（SVT）的药物，并为其在临床环境中的安全使用提供参考。方法我们分析了2004年至2023年第一季度的数据，这些数据是通过使用关键词搜索OpenVigil数据库获得的“室上性心动过速。”通过查询RxNav数据库获得商品名和通用名，并汇总比例。还总结了比例报告比（PRR）、报告比值比和卡方值。我们创建了 Asahi 图，并将筛选标准设置为药物事件≥30、PRR >2 和卡方 >4。使用副作用资源数据库、多个科学文献数据库和杭州益药合理用药系统对结果进行评估。结果 2004 年第一季度至 2023 年间，总共发现 2435 种不同药物可诱发 SVT，导致 22,375 例记录在案的不良事件相关到 SVT。进一步调查显示，沙丁胺醇、帕罗西汀、福莫特罗、紫杉醇、文拉法辛和茶碱最有可能引起SVT。结论我们利用OpenVigil数据库对药物不良事件进行信号挖掘，评估了最有可能引起SVT的六种药物。本研究结果可为临床用药安全提供参考。