HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway,mBio

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HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway
mBio ( IF 6.4 ) Pub Date : 2024-03-26 , DOI: 10.1128/mbio.00348-24
Jenna E. Eschbach ₁ , Maritza Puray-Chavez ₁ , Shawn Mohammed ₁ , Qiankun Wang ₂ , Ming Xia ₁ , Lin-Chen Huang ₁ , Liang Shan _{2,

3} , Sebla B. Kutluay ₁

Affiliation

In HIV-1 particles, the dimeric RNA genome and associated viral proteins and enzymes are encased in a proteinaceous lattice composed of the viral capsid protein. Herein, we assessed how altering the stability of this capsid lattice through orthogonal ...

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