Aging and genetic‐related disorders in the human brain lead to impairment of daily cognitive functions. Due to their neural synaptic complexity and the current limits of knowledge, reversing these disorders remains a substantial challenge for Brain‐Computer Interfaces (BCI). In this work, we provide a solution to potentially override aging and neurological disorder‐related cognitive function loss in the human brain through the application of our quantum synaptic device. To illustrate this point, we design and develop a quantum topological insulator (QTI) Bi2Se2Te‐based synaptic neuroelectronic device, where the electric field‐induced tunable topological surface edge states and quantum switching properties make them a premier option for establishing artificial synaptic neuromodulation approaches. Leveraging these unique quantum synaptic properties, our developed synaptic device provides the capability to neuromodulate distorted neural signals, leading to the reversal of age‐related disorders via BCI. With the synaptic neuroelectronic characteristics of our device, we demonstrate excellent efficacy in treating cognitive neural dysfunctions through modulated neuromorphic stimuli. As a proof of concept, we demonstrate real‐time neuromodulation of electroencephalogram (EEG) deduced distorted event‐related potentials (ERP) by modulation of our synaptic device array.This article is protected by copyright. All rights reserved

中文翻译：

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用于脑机接口的拓扑量子开关启用神经电子突触调制器

人类大脑的衰老和遗传相关疾病会导致日常认知功能受损。由于神经突触的复杂性和当前知识的限制，扭转这些疾病仍然是脑机接口（BCI）面临的重大挑战。在这项工作中，我们提供了一种解决方案，通过应用我们的量子突触装置来潜在地克服人脑中衰老和神经系统疾病相关的认知功能丧失。为了说明这一点，我们设计并开发了量子拓扑绝缘体（QTI）Bi2硒2基于Te的突触神经电子器件，其中电场诱导的可调谐拓扑表面边缘态和量子开关特性使它们成为建立人工突触神经调节方法的首选。利用这些独特的量子突触特性，我们开发的突触装置提供了神经调节扭曲神经信号的能力，从而通过脑机接口逆转与年龄相关的疾病。凭借我们设备的突触神经电子特性，我们在通过调节神经形态刺激治疗认知神经功能障碍方面表现出优异的功效。作为概念证明，我们展示了脑电图（EEG）的实时神经调节，通过调节我们的突触装置阵列推导出扭曲的事件相关电位（ERP）。本文受版权保护。版权所有