Breast cancer and genital cancer are known as cancers that affect people’s relationships with their partners. Women with such cancers are emotionally vulnerable and need more support from their partners. The present systematic review and meta-analysis evaluated the effectiveness of couple-based interventions on the marital outcomes of patients with these cancers and their intimate partners. To perform this systematic review, Google Scholar and databases such as PubMed, Web of Science, Cochrane, Scopus, SID (Scientific Information Database), and Magiran were searched systematically. The reviewed studies included randomized controlled trials and quasiexperimental studies in which the intervention group, couple-based interventions, and the control group received routine care, general education or no intervention for cancer treatment. In this study, the included participants were patients with breast cancer or genital cancer and their intimate partners. The primary outcomes considered in this study included patients’ marital adjustment, patients’ marital satisfaction, patients’ marital intimacy, and patients’ marital relationships. The secondary outcomes were partners’ marital adjustment, partners’ marital satisfaction, partners’ marital intimacy, and partners’ marital relationships. A meta-analysis was performed with Review Manager v. 5.3 software (The Nordic Cochrane Centre, Cochrane Collaboration, 2014; Copenhagen, Denmark). The intervention impacts on continuous outcomes were measured using standardized mean differences (SMDs) with 95% confidence interval because of the use of various scales to evaluate the outcomes. The quality of evidence presented in the included studies was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. In the subgroup analysis, the studied outcomes were divided into two parts (theory-based and non-theory-based) in terms of the theoretical context of couple-based interventions. From a total of 138 retrieved studies, 14 trials were eligible for inclusion in the study. The results of the meta-analysis showed that the patient’s marital satisfaction increased significantly with couple-based interventions (SMD 0.46, 95% confidence interval 0.07 to 0.85; 7 trials, 341 patients, very low certainty) compared to the control group, but the evidence was uncertain. However, there were no significant differences between the groups in the partner’s marital satisfaction, the patient’s and partner’s marital adjustment, and the patient’s and partner’s marital intimacy. Additionally, the results of the subgroup analysis showed that the couple-based interventions significantly increased the patient’s marital adjustment (SMD 1.96, 95% CI 0.87 to 3.06; 4 trials, 355 patients, very low certainty), the partner’s marital adjustment (SMD 0.53, 95% CI 0.20 to 0.86; 4 trials, 347 partners, very low certainty), the patient’s marital satisfaction (SMD 0.89, 95% CI 0.35 to 1.43; 2 trials, 123 patients, very low certainty), and the partner’s marital satisfaction (SMD 0.57, 95% CI 0.20 to 0.94; 2 trials, 123 partners, very low certainty) compared to the control group in theory-based studies. In. However, in non-theory-based studies, the results of the meta-analysis revealed no significant differences between the intervention and control groups. The results of this study demonstrated the impact of couple-based interventions on the marital outcomes of patients with breast and genital cancers. Because of the very low confidence in the evidence, high-quality randomized trials with a sufficient sample size should be conducted considering the proper theoretical context.

中文翻译：

---

基于夫妇的干预措施对患有生殖器癌和乳腺癌的妇女及其伴侣的婚姻结局的有效性：系统评价和荟萃分析

乳腺癌和生殖器癌症被称为影响人们与伴侣关系的癌症。患有此类癌症的女性在情感上很脆弱，需要伴侣的更多支持。本系统评价和荟萃分析评估了基于夫妇的干预措施对这些癌症患者及其亲密伴侣婚姻结局的有效性。为了进行这项系统综述，系统地检索了 Google Scholar 和 PubMed、Web of Science、Cochrane、Scopus、SID（科学信息数据库）和 Magiran 等数据库。审查的研究包括随机对照试验和准实验研究，其中干预组、基于夫妇的干预措施和对照组接受常规护理、普通教育或不干预癌症治疗。在这项研究中，纳入的参与者是乳腺癌或生殖器癌症患者及其亲密伴侣。本研究考虑的主要结局包括患者的婚姻调整、患者的婚姻满意度、患者的婚姻亲密程度以及患者的婚姻关系。次要结果是伴侣的婚姻调整、伴侣的婚姻满意度、伴侣的婚姻亲密度和伴侣的婚姻关系。使用 Review Manager v. 5.3 软件进行荟萃分析（北欧 Cochrane 中心，Cochrane 协作中心，2014 年；丹麦哥本哈根）。由于使用不同的量表来评估结果，因此使用具有 95% 置信区间的标准化平均差 (SMD) 来衡量干预措施对连续结果的影响。使用建议评估、制定和评价分级（GRADE）方法对纳入研究中提出的证据质量进行了评估。在亚组分析中，根据夫妻干预的理论背景，将研究结果分为两部分（基于理论和非理论）。在总共 138 项检索到的研究中，有 14 项试验符合纳入该研究的条件。荟萃分析的结果显示，与对照组相比，基于夫妇的干预措施使患者的婚姻满意度显着提高（SMD 0.46，95%置信区间0.07至0.85；7项试验，341名患者，确定性非常低），但证据不确定。然而，在伴侣的婚姻满意度、患者和伴侣的婚姻调整以及患者和伴侣的婚姻亲密度方面，各组之间没有显着差异。此外，亚组分析结果显示，基于夫妻的干预措施显着提高了患者的婚姻调整（SMD 1.96，95% CI 0.87至3.06；4项试验，355名患者，确定性非常低）、伴侣的婚姻调整（SMD 0.53） ，95% CI 0.20 至 0.86；4 项试验，347 名伴侣，确定性极低），患者的婚姻满意度（SMD 0.89，95% CI 0.35 至 1.43；2 项试验，123 名患者，非常低确定性）以及伴侣的婚姻满意度（SMD 0.57，95% CI 0.20 至 0.94；2 项试验，123 名伴侣，非常低确定性）与基于理论的研究中的对照组进行比较。在。然而，在非理论研究中，荟萃分析的结果显示干预组和对照组之间没有显着差异。这项研究的结果证明了基于夫妇的干预措施对乳腺癌和生殖器癌症患者婚姻结局的影响。由于证据的置信度非常低，因此应考虑适当的理论背景，进行具有足够样本量的高质量随机试验。