The cardiometabolic index (CMI) is a new metric derived from the triglyceride-glucose index and body mass index and is considered a potential marker for cardiovascular risk assessment. This study aimed to examine the correlation between the CMI and the presence and severity of arteriosclerosis in patients with type 2 diabetes mellitus (T2DM). This study involved 2243 patients with T2DM. The CMI was derived by dividing the triglyceride level (mmol/L) by the high-density lipoprotein level (mmol/L) and then multiplying the quotient by the waist-to-height ratio. Multivariate logistic regression was used to analyze the correlations between the CMI and BMI blood biomarkers, blood pressure, and brachial-ankle pulse wave velocity (baPWV). Patients were categorized into three groups based on their CMI: Group C1 (CMI < 0.775; n = 750), Group C2 (CMI: 0.775–1.355; n = 743), and Group C3 (CMI > 1.355; n = 750). Increased BMI, fasting glucose, insulin (at 120 min), total cholesterol (TC), and baPWV values were observed in Groups C2 and C3, with statistically significant trends (all trends P < 0.05). The CMI was positively correlated with systolic blood pressure (r = 0.74, P < 0.001). Multivariate analysis revealed that an increased CMI contributed to a greater risk for arteriosclerosis (OR = 1.87, 95%CI: 1.66–2.10, P < 0.001). Compared to the C1 group, the C2 group and C3 group had a greater risk of developing arteriosclerosis, with ORs of 4.55 (95%CI: 3.57–5.81, P<0.001) and 5.56 (95%CI: 4.32–7.17, P<0.001), respectively. The association was notably stronger in patients with a BMI below 21.62 kg/m² than in those with a BMI of 21.62 kg/m² or higher (OR = 4.53 vs. OR = 1.59). These findings suggest that the CMI is a relevant and independent marker of arteriosclerosis in patients with T2DM and may be useful in the risk stratification and management of these patients.

中文翻译：

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2型糖尿病患者心脏代谢指数与动脉硬化的相关性

心脏代谢指数（CMI）是源自甘油三酯-葡萄糖指数和体重指数的新指标，被认为是心血管风险评估的潜在标志。本研究旨在探讨 2 型糖尿病 (T2DM) 患者的 CMI 与动脉硬化的存在和严重程度之间的相关性。这项研究涉及 2243 名 T2DM 患者。 CMI 的计算方法是将甘油三酯水平 (mmol/L) 除以高密度脂蛋白水平 (mmol/L)，然后将商乘以腰围与身高之比。采用多变量逻辑回归分析 CMI 和 BMI 血液生物标志物、血压和臂踝脉搏波速度 (baPWV) 之间的相关性。根据 CMI 将患者分为三组：C1 组（CMI < 0.775；n = 750）、C2 组（CMI：0.775–1.355；n = 743）和 C3 组（CMI > 1.355；n = 750）。在 C2 和 C3 组中观察到 BMI、空腹血糖、胰岛素（120 分钟）、总胆固醇 (TC) 和 baPWV 值增加，具有统计学显着趋势（所有趋势 P < 0.05）。 CMI与收缩压呈正相关（r=0.74，P<0.001）。多变量分析显示，CMI 增加导致动脉硬化风险增加（OR = 1.87，95%CI：1.66–2.10，P < 0.001）。与C1组相比，C2组和C3组发生动脉硬化的风险更大，OR分别为4.55（95%CI：3.57~5.81，P<0.001）和5.56（95%CI：4.32~7.17，P< 0.001），分别。 BMI 低于 21.62 kg/m2 的患者的这种相关性明显强于 BMI 21.62 kg/m2 或更高的患者（OR = 4.53 vs. OR = 1.59）。这些发现表明，CMI 是 T2DM 患者动脉硬化的相关且独立的标志物，可能有助于这些患者的风险分层和管理。