The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has emerged as a global public health concern and its sequels have barely started to outcrop. A good percentage of patients who suffered from COVID-19 are prone to develop long-COVID or post-COVID condition (PCC), a multisystemic, heterogeneous, chronic disorder. Patients with PCC may experience diverse manifestations, of which cardiovascular and neurological symptoms are among the most frequently reported. Indeed, dysautonomia presented as orthostatic intolerance has gained room following recent reports linking postural orthostatic tachycardia syndrome (POTS) with PCC. Disturbances in heart rate (HR) and blood pressure (BP) during postural changes are the cornerstones of orthostatic intolerance seen in patients suffering from PCC. A subtype of POTS, hyperadrenergic POTS, has been widely studied because of its association with mast cell activation syndrome (MCAS). Although a causative relationship between PCC, hyperadrenergic POTS, and MCAS remains unrevealed, these syndromes can overlap. We want to propose here a correlation produced by a close-loop mechanism with positive feedback established after SARS-CoV-2 infection in a previously healthy young patient.

中文翻译：

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继发于长冠状病毒病综合征的顽固性高肾上腺素能体位性心动过速综合征患者使用组胺阻滞剂完全缓解。

由新型严重急性呼吸综合征冠状病毒 2 型 (SARS-CoV-2) 引起的 COVID-19 大流行已成为全球公共卫生问题，其后果才刚刚开始显现。很大一部分患有 COVID-19 的患者很容易出现长期 COVID 或 COVID 后病症 (PCC)，这是一种多系统、异质性慢性疾病。 PCC 患者可能会出现多种表现，其中心血管和神经系统症状是最常见的症状。事实上，在最近将姿势性直立性心动过速综合征 (POTS) 与 PCC 联系起来之后，以直立性不耐受为表现的自主神经功能障碍已经获得了更多的空间。姿势改变期间心率 (HR) 和血压 (BP) 的紊乱是 PCC 患者体位不耐受的基石。 POTS 的一种亚型——肾上腺素能亢进型 POTS，因其与肥大细胞激活综合征 (MCAS) 的相关性而得到了广泛研究。尽管 PCC、肾上腺素能亢进性 POTS 和 MCAS 之间的因果关系尚未揭示，但这些综合征可能会重叠。我们想在这里提出一种由闭环机制产生的相关性，该机制与先前健康的年轻患者感染 SARS-CoV-2 后建立的正反馈相关。