Alcohol use disorder is associated with overvaluation of alcohol relative to other rewards, in part due to dynamic increases in value in response to alcohol-related cues. In a neuroeconomic framework, alcohol cues increase behavioral economic demand for alcohol, but the neural correlates these cue effects are unknown. This functional magnetic resonance imaging study combined a neuroeconomic alcohol purchase task with an alcohol cue exposure in 72 heavy drinkers with established sensitivity to alcohol cues (51 % female; mean age=33.74). Participants reported how many drinks they would consume from $0-$80/drink following exposure to neutral and alcohol images in a fixed order. Participants purchased significantly more drinks in the alcohol compared to the neutral condition, which was also evident for demand indices (i.e., intensity, breakpoint, Omax, elasticity; s<0.001; s=0.46–0.92). Alcohol purchase decisions were associated with activation in rostral middle and medial frontal gyri, anterior insula, posterior parietal cortex, and dorsal striatum, among other regions. Activation was lower across regions in the alcohol relative to neutral cue condition, potentially due to greater automaticity of choices in the presence of alcohol cues or attenuation of responses due to fixed cue order. These results contribute to growing literature using neuroeconomics to understand alcohol misuse and provide a foundation for future research investigating decision-making effects of environmental alcohol triggers.

中文翻译：

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成年重度饮酒者暴露于酒精提示后酒精需求增加的神经相关性

酒精使用障碍与酒精相对于其他奖励的高估有关，部分原因是酒精相关线索的价值动态增加。在神经经济学框架中，酒精暗示会增加对酒精的行为经济需求，但这些暗示效应的神经关联尚不清楚。这项功能性磁共振成像研究将神经经济学酒精购买任务与酒精提示暴露结合起来，研究对象是 72 名对酒精提示敏感的重度饮酒者（51% 为女性；平均年龄 = 33.74）。参与者报告了在按固定顺序接触中性图像和酒精图像后，他们会喝多少饮料（每杯 0-80 美元）。与中性条件相比，参与者购买了更多的酒精饮料，这对于需求指数（即强度、断点、Omax、弹性；s<0.001；s=0.46-0.92）也很明显。购买酒精的决定与头侧中回和内侧额回、前岛叶、后顶叶皮质和背侧纹状体等区域的激活有关。相对于中性提示条件，酒精中各区域的激活较低，这可能是由于在酒精提示存在的情况下选择的自动化程度更高，或者由于固定的提示顺序而导致反应减弱。这些结果有助于增加利用神经经济学来理解酒精滥用的文献，并为未来调查环境酒精触发因素的决策影响的研究奠定基础。