Single-chain nanoparticles (SCNPs) show great promise in biomedical applications, due to their unique properties in ultra-small size, high porosity, and ease of functionalization. Traditional synthesis protocols for SCNPs often result in high polydispersity of size and deviations from globular compact conformations, accompanied by challenges such as high energy consumption and low yield. By means of simulation, we propose an innovative method for the synthesis of SCNPs through a co-assembly nanoreactor. This protocol adeptly avoids intermolecular aggregation of the precursor chain under poor solvent conditions by crosslinking inside the central cavity of nanoreactors formed by co-assembled nanorods, significantly enhancing the quality and efficiency of the SCNP synthesis. Our results pave the way for the synthesis of SCNP with highly controllable size/topology, with potential applications in nanocarrier, drug delivery, and cell uptake, among other fields.

中文翻译：

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用于高效合成单链纳米颗粒的共组装纳米反应器方案

单链纳米粒子（SCNP）由于其超小尺寸、高孔隙率和易于功能化的独特特性，在生物医学应用中显示出巨大的前景。传统的 SCNP 合成方案通常会导致尺寸的高度多分散性和球状致密构象的偏差，并伴随着高能耗和低产率等挑战。通过模拟，我们提出了一种通过共组装纳米反应器合成 SCNP 的创新方法。该方案通过在共组装纳米棒形成的纳米反应器的中心腔内进行交联，巧妙地避免了在不良溶剂条件下前体链的分子间聚集，从而显着提高了 SCNP 合成的质量和效率。我们的研究结果为合成尺寸/拓扑高度可控的 SCNP 铺平了道路，在纳米载体、药物输送和细胞摄取等领域具有潜在的应用。