Non-human primates (NHPs) have played a crucial role in our understanding of epilepsy, given their striking similarities with humans. Through their use, we have gained a deeper understanding of the neurophysiology and pathophysiology of epileptic seizures, and they have proven invaluable allies in developing anti-seizure therapies. This review explores the history of NHPs as natural models of epilepsy, discusses the findings obtained after exposure to various chemoconvulsant drugs and focal electrical stimulation protocols that helped uncover important mechanisms related to epilepsy, examines diverse treatments to prevent and manage epilepsy, and addresses essential ethical issues in research. In this review, we aim to emphasize the important role of NHPs in epilepsy research and summarize the benefits and challenges associated with their use as models.

中文翻译：

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我们从非人类灵长类动物作为癫痫动物模型中学到了什么

鉴于非人类灵长类动物（NHP）与人类惊人的相似性，它们在我们对癫痫的理解中发挥了至关重要的作用。通过它们的使用，我们对癫痫发作的神经生理学和病理生理学有了更深入的了解，并且它们已被证明是开发抗癫痫疗法的宝贵盟友。这篇综述探讨了 NHP 作为癫痫自然模型的历史，讨论了接触各种化学惊厥药物和局部电刺激方案后获得的发现，这些发现有助于揭示与癫痫相关的重要机制，检查预防和管理癫痫的多种治疗方法，并解决基本的伦理问题研究中的问题。在这篇综述中，我们旨在强调 NHP 在癫痫研究中的重要作用，并总结与将其用作模型相关的益处和挑战。