This study aims to investigate the difference between epilepsy comorbid with and without cognitive dysfunction. Participants were classified into patients with epilepsy comorbid cognitive dysfunction (PCCD) and patients with epilepsy without comorbid cognitive dysfunction (nPCCD). Microstate analysis was applied based on 20-channel electroencephalography (EEG) to detect the dynamic changes in the whole brain. The coverage, occurrence per second, duration, and transition probability were calculated. The occurrence per second and the coverage of microstate B in the PCCD group were higher than that of the nPCCD group. Coverage in microstate D was lower in the PCCD group than in the nPCCD group. In addition, the PCCD group has a higher probability of A to B and B to A transitions and a lower probability of A to D and D to A transitions. Our research scrutinizes the disparities observed within EEG microstates among epilepsy patients both with and without comorbid cognitive dysfunction. EEG microstate analysis offers a novel metric for assessing neuropsychiatric disorders and supplies evidence for investigating the mechanisms and the dynamic change of epilepsy comorbid cognitive dysfunction.

中文翻译：

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伴有或不伴有认知功能障碍的癫痫的脑电图微观状态：内在大脑活动的改变

本研究旨在探讨伴有和不伴有认知功能障碍的癫痫共病之间的差异。参与者被分为患有癫痫共病认知功能障碍（PCCD）的患者和不患有共病认知功能障碍的癫痫患者（nPCCD）。基于20通道脑电图（EEG）的微状态分析来检测整个大脑的动态变化。计算了覆盖范围、每秒发生次数、持续时间和转移概率。 PCCD组微状态B的每秒出现次数和覆盖率均高于nPCCD组。 PCCD 组中微状态 D 的覆盖率低于 nPCCD 组。此外，PCCD组具有较高的A到B和B到A转变的概率以及较低的A到D和D到A转变的概率。我们的研究仔细观察了患有或不患有认知功能障碍的癫痫患者脑电图微观状态中观察到的差异。脑电图微状态分析为评估神经精神疾病提供了一种新的指标，并为研究癫痫共病认知功能障碍的机制和动态变化提供了证据。