In the current era of the World Health Organization's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022–2031 (IGAP), precise and updated estimates of epilepsy burden are vital in formulating policies to improve the care of persons with epilepsy, especially in Asian countries with significant treatment gap. Hence, we aimed to consolidate the available data and quantify epilepsy prevalence and incidence estimates in Asian countries. We systematically searched PubMed, Embase, Ovid, and Scopus databases from inception until March 2023 for studies reporting epilepsy prevalence and incidence in Asian countries. We applied random effects -analysis to generate the pooled prevalence and incidence using the package in R. Additionally, we performed a subgroup -analysis to explore the potential sources of heterogeneity. A -regression analysis was conducted to examine the trend of epilepsy over time. A total of 99 studies with 100,654,124 participants were included in the -analysis. The pooled prevalence was 5.6 per 1000 (95 % confidence interval (CI) 4.4–6.8) for active epilepsy and 6.7 per 1000 (95 % CI 5.7–7.9) for lifetime epilepsy. The pooled incidence rate of epilepsy was 52.5 per 100,000 person-years (95 % CI 42.7–79.4). The subgroup analysis revealed a higher prevalence of active epilepsy (6.7/1000) and lifetime epilepsy (8.6/1000) in West Asia than in other regions. The funnel plot and Egger's test (p-value =<0.0001) revealed publication bias for active epilepsy. Our findings highlight a high prevalence of active and lifetime epilepsy in West Asia and emphasize the necessity of implementing and formulating specific strategies to tackle the epilepsy burden in this region. Furthermore, high-quality epidemiological studies incorporating economic burdens and comorbidities associated with epilepsy in Asia are still needed.

中文翻译：

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估计亚洲国家癫痫的活跃和终生患病率和发病率：系统评价和荟萃分析

在世界卫生组织《2022-2031 年癫痫和其他神经疾病跨部门全球行动计划》(IGAP) 的当前时代，精确和更新的癫痫负担估计对于制定改善癫痫患者护理的政策至关重要，特别是在亚洲治疗差距显着的国家。因此，我们的目的是整合现有数据并量化亚洲国家的癫痫患病率和发病率估计。我们系统地检索了 PubMed、Embase、Ovid 和 Scopus 数据库，从建库到 2023 年 3 月，寻找报告亚洲国家癫痫患病率和发病率的研究。我们应用随机效应分析来使用 R 中的包生成汇总患病率和发病率。此外，我们还进行了亚组分析以探索异质性的潜在来源。进行回归分析以检查癫痫随时间的变化趋势。分析中总共纳入了 99 项研究，涉及 100,654,124 名参与者。活动性癫痫的汇总患病率为每 1000 人 5.6 例（95% 置信区间 (CI) 4.4–6.8），终生性癫痫的患病率为每 1000 人 6.7 例（95% CI 5.7–7.9）。癫痫的汇总发病率为每 10 万人年 52.5 例（95% CI 42.7–79.4）。亚组分析显示，西亚活动性癫痫（6.7/1000）和终生癫痫（8.6/1000）的患病率高于其他地区。漏斗图和 Egger 检验（p 值 =<0.0001）揭示了活动性癫痫的发表偏倚。我们的研究结果强调了西亚活动性和终生癫痫的高患病率，并强调有必要实施和制定具体策略来解决该地区的癫痫负担。此外，仍然需要将亚洲癫痫相关的经济负担和合并症纳入高质量的流行病学研究。