IntroductionLoss of muscle mass and the accumulation of visceral fat are known risk factors for the deterioration of glycemic control in type 2 diabetes mellitus. This study looked at the effects of such factors on glycemic control in Japanese patients with type 2 diabetes mellitus in the form of handgrip strength (HGS) and waist circumference (WC).Materials and MethodsIn this prospective, observational study, 233 patients with type 2 diabetes mellitus and a HbA1c level of ≥7.0% were followed for around 1 year, during which time they were studied for an understanding of the association between handgrip strength, waist circumference, and glycemic control (HbA1c <7.0%). Hazard ratios (HRs) and 95% confidence intervals (CIs) for glycemic control improvement by Cox hazards models were analyzed for handgrip strength and waist circumference.ResultsCompared with the low tertile, patients in the middle and high tertiles of handgrip strength when adjustment was carried out for waist circumference were 2.117 (1.142–3.924) and 4.670 (2.526–8.632), respectively. The HRs of patients in the middle and high tertiles of WC when adjustment was made for HGS were 0.442 (0.269–0.725) and 0.339 (0.191–0.604), respectively. Within the low, middle, and high HGS tertiles, the HRs for WC were 0.863 (0.797–0.934), 0.940 (0.899–0.982), and 1.009 (0.984–1.035), respectively, although the HRs for HGS within each WC tertile remained significant.ConclusionsHandgrip strength and waist circumference demonstrated independent associations for glycemic control, but the effect of waist circumference appeared to be at least partially canceled out by increased handgrip strength. The data suggest that handgrip strength might help to mitigate the negative impact of waist circumference on glycemic control.

中文翻译：

---

握力和腰围对血糖控制的影响：利用日本 2 型糖尿病患者门诊临床数据进行的前瞻性观察性研究

简介肌肉质量的损失和内脏脂肪的积累是 2 型糖尿病血糖控制恶化的已知危险因素。本研究以握力 (HGS) 和腰围 (WC) 的形式探讨这些因素对日本 2 型糖尿病患者血糖控制的影响。 材料和方法在这项前瞻性观察性研究中，233 名 2 型糖尿病患者参与了研究对患有糖尿病且 HbA1c 水平≥7.0% 的患者进行了约 1 年的随访，在此期间对他们进行了研究，以了解握力、腰围和血糖控制 (HbA1c <7.0%) 之间的关联。通过Cox风险模型对握力和腰围改善血糖控制的风险比（HR）和95％置信区间（CI）进行分析。结果与低三分位数相比，进行调整时握力中三分位数和高三分位数的患者腰围分别为 2.117 (1.142–3.924) 和 4.670 (2.526–8.632)。当对 HGS 进行调整时，WC 中三分位数和高三分位患者的 HR 分别为 0.442 (0.269–0.725) 和 0.339 (0.191–0.604)。在低、中和高 HGS 三分位数内，WC 的 HR 分别为 0.863 (0.797–0.934)、0.940 (0.899–0.982) 和 1.009 (0.984–1.035)，尽管每个 WC 三分位数内的 HGS HR 仍然存在结论握力和腰围与血糖控制有独立的相关性，但腰围的影响似乎至少部分被握力的增加所抵消。数据表明，握力可能有助于减轻腰围对血糖控制的负面影响。