A heart-on-a-particle model based on multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs. The relevant microgel was fabricated by a biocompatible microfluidic-based approach, where heart function-related HL-1 and HUVEC cells were arranged in separate compartments. Finally, the mechanism of aconitine-induced heart toxicity was elucidated using mass spectrometry and molecular biotechnology.

中文翻译：

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用微流体装置制备的心脏颗粒评价乌头碱的心脏毒性

提出了一种基于多室微凝胶的心脏颗粒模型来模拟心脏微环境并研究药物的心脏毒性。相关的微凝胶是通过生物相容性微流体方法制造的，其中与心脏功能相关的 HL-1 和 HUVEC 细胞排列在单独的隔室中。最后，利用质谱和分子生物技术阐明了乌头碱引起的心脏毒性的机制。