Metastasis arises from cancer-cell intrinsic adaptations and permissive tumor microenvironments (TME) that are distinct across different organs. Deciphering the mechanisms underpinning organotropism could provide novel preventive and therapeutic strategies for cancer patients. Rogava and colleagues identified Pip4kc as a driver of liver metastasis, acting by sensitizing cancer cells to insulin-dependent PI3K/AKT signaling, which could be reversed by dual pharmacological inhibition of PI3K and SGLT2 or a ketogenic diet. The study highlights the importance of tumor: microenvironment communication in the context of systemic physiology and points towards potential combination therapies.

中文翻译：

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癌细胞劫持生理代谢信号以促进肝转移

转移源于癌细胞的内在适应和不同器官之间不同的允许的肿瘤微环境（TME）。破译支持器官趋向性的机制可以为癌症患者提供新的预防和治疗策略。 Rogava 及其同事发现 Pip4kc 是肝转移的驱动因素，通过使癌细胞对胰岛素依赖性 PI3K/AKT 信号变得敏感来发挥作用，而这种信号可以通过 PI3K 和 SGLT2 的双重药理抑制或生酮饮食来逆转。该研究强调了肿瘤的重要性：系统生理学背景下的微环境通讯，并指出了潜在的联合疗法。