The etiology of spaceflight-associated neuro-ocular syndrome (SANS) is a developing field of research, with many current hypotheses receiving varying degrees of support. In this article, three prominent risk factors including zero gravity conditions, extraterrestrial hypercapnic environments, and individual genetic predisposition are described and their pathophysiological pathways are compared. In addition, glymphatic system impairment is explored as a potential mutual endpoint for these pathways in the development of SANS.

中文翻译：

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航天相关神经眼综合征：潜在病因及其与类淋巴系统的联系

航天相关神经眼综合征（SANS）的病因学是一个正在发展的研究领域，目前许多假设都得到了不同程度的支持。在本文中，描述了三个突出的危险因素，包括零重力条件、地外高碳酸环境和个体遗传倾向，并比较了它们的病理生理学途径。此外，类淋巴系统损伤被探索为 SANS 发展过程中这些途径的潜在共同终点。