A recent study by Tran et al.¹⁰ investigated the cellular processes underlying the timing and regulation of oligodendrocyte production, focusing on the role of Notch signaling in the dorsal forebrain of mouse embryos. They found that while Notch signaling is required to specify oligodendrocyte precursor cell fate during embryonic development, over-expression prevents oligodendrogenesis through several mechanisms. This critical review highlights their findings, offering several suggestions for future research investigating the precise spatiotemporal control of Notch signaling throughout the development of the central nervous system.

中文翻译：

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神经元-胶质细胞开关中缺口信号的动态：平衡行为

Tran 等人最近的一项研究。¹⁰研究了少突胶质细胞产生的时间和调节的细胞过程，重点关注 Notch 信号在小鼠胚胎背侧前脑中的作用。他们发现，虽然在胚胎发育过程中需要Notch信号传导来指定少突胶质细胞前体细胞的命运，但过度表达会通过多种机制阻止少突胶质细胞的发生。这篇批判性评论强调了他们的发现，为未来研究中枢神经系统发育过程中 Notch 信号的精确时空控制的研究提供了一些建议。