There is growing evidence that altered microbiota abundance of a range of specific anaerobic bacteria are associated with cancer, including Peptoniphilus spp., Porphyromonas spp., Fusobacterium spp., Fenollaria spp., Prevotella spp., Sneathia spp., Veillonella spp. and Anaerococcus spp. linked to multiple cancer types. In this review we explore these pathogenic associations. The mechanisms by which bacteria are known or predicted to interact with human cells are reviewed and we present an overview of the interlinked mechanisms and hypotheses of how multiple intracellular anaerobic bacterial pathogens may act together to cause host cell and tissue microenvironment changes associated with carcinogenesis and cancer cell invasion. These include combined effects on changes in cell signalling, DNA damage, cellular metabolism and immune evasion. Strategies for early detection and eradication of anaerobic cancer-associated bacterial pathogens that may prevent cancer progression are proposed.

中文翻译：

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癌症侵袭和厌氧细菌：机制的新见解

越来越多的证据表明，一系列特定厌氧菌的微生物丰度改变与癌症相关，包括嗜胃杆菌属、卟啉单胞菌属、梭杆菌属、芬诺拉菌属、普雷沃氏菌属、斯尼西亚属、韦荣球菌属。和厌氧球菌属。与多种癌症类型有关。在这篇综述中，我们探讨了这些致病关联。回顾了已知或预测的细菌与人类细胞相互作用的机制，并概述了多种细胞内厌氧细菌病原体如何共同作用，导致与致癌和癌症相关的宿主细胞和组织微环境变化的相互关联的机制和假设细胞侵袭。这些包括对细胞信号传导变化、DNA 损伤、细胞代谢和免疫逃避的综合影响。提出了早期检测和根除可能阻止癌症进展的厌氧癌症相关细菌病原体的策略。