Strontium (Sr), a trace element with a long history and a significant presence in the Earth’s crust, plays a critical yet often overlooked role in various biological processes affecting human health. This comprehensive review explores the multifaceted implications of Sr, especially in the context of non-communicable diseases (NCDs) such as cardiovascular diseases, osteoporosis, hypertension, and diabetes mellitus. Sr is predominantly acquired through diet and water and has shown promise as a clinical marker for calcium absorption studies. It contributes to the mitigation of several NCDs by inhibiting oxidative stress, showcasing antioxidant properties, and suppressing inflammatory cytokines. The review delves deep into the mechanisms through which Sr interacts with human physiology, emphasizing its uptake, metabolism, and potential to prevent chronic conditions. Despite its apparent benefits in managing bone fractures, hypertension, and diabetes, current research on Sr’s role in human health is not exhaustive. The review underscores the need for more comprehensive studies to solidify Sr’s beneficial associations and address the gaps in understanding Sr intake and its optimal levels for human health.

中文翻译：

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微量元素锶与人类健康：综合分析在炎症和非传染性疾病（NCD）中的作用

锶（Sr）是一种历史悠久、在地壳中大量存在的微量元素，在影响人类健康的各种生物过程中发挥着至关重要但经常被忽视的作用。这篇全面的综述探讨了锶的多方面影响，特别是在心血管疾病、骨质疏松症、高血压和糖尿病等非传染性疾病 (NCD) 的背景下。 Sr 主要通过饮食和水获得，并已显示出作为钙吸收研究的临床标志物的前景。它通过抑制氧化应激、展现抗氧化特性和抑制炎症细胞因子，有助于缓解多种非传染性疾病。该综述深入探讨了锶与人体生理相互作用的机制，强调了它的吸收、代谢和预防慢性疾病的潜力。尽管锶在治疗骨折、高血压和糖尿病方面具有明显的益处，但目前对锶在人类健康中的作用的研究并不详尽。该审查强调需要进行更全面的研究，以巩固锶的有益关联，并解决在了解锶摄入量及其对人类健康的最佳水平方面的差距。